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KMID : 0386319780110010049
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Korean Leprosy Bulletin
1978 Volume.11 No. 1 p.49 ~ p.52
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The Effects of Rifampicin in the Lepromatous Leprosy (A Preliminary Report)
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Kang Woo Lee
Won Houh/Shi Ryong Choi
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Abstract
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Therapeutic effects of rifampicin (300 mg per day), both clinically and bacteriologically, were observed among 13 lepromatous leprosy patients for 2 to 25 months. It was evident that the fall of BI was gradual and the decrease of MI was very rapid in all cases. From the results of clinical signs, 6 out of the 13 patients improved markedly, 2 moderately and 5 slightly. One of the most favourable signs of clinical improvement was that nodules and raised skin became absorbed and flattened in a short time. Erythema nodosum leprosum (ENL) and neuritis were seen in 6 out of the 13 patients (moderate ENL 3 cases and mild ENL 3 cases), but the symptoms were controlled with thalidomide and prednisolone. The patients with ENL required treatment of a rather prolonged period and showed a tendency of gradual fall in BI and MI during treatment. There were no significant changes in the complete blood count, platelet count, SGOT and SGPT except in the lymphocyte count, which slightly increased during the treatment. No side effects were observed in any cases.
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